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This impairment is particularly problematic during aging, as both DNA damage accumulation and NAD+ depletion occur simultaneously, creating a vicious cycle where reduced repair capacity leads to further DNA damage accumulation

Under biotic and abiotic stresses, plant cells exhibit a rapid synthesis of nitric oxide (NO) and a parallel accumulation of reactive oxygen species (ROS)

Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, et al

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This review provides an integrated overview of the factors driving chiral discrimination of 2HG, its contribution to tumor heterogeneity, and its influence on therapy resistance