Nebulizing Therapy
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Description
Somigliana E, Sarais V, Reschini M, et al
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Denton CP, Khanna D
In neuroendocrine prostate tumors, loss of tumor suppressor protein kinase C (PKC) / enhanced serine metabolism through mTORC1/ATF4/PHGDH axis, which leads to aberrant DNA methylation by increased one-carbon metabolic flux, ultimately leading to treatment resistance and poor prognosis [98]
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A schematic diagram of outcomes was shown in Fig 2
