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Manual annotation based on canonical markers separated cells into non-endothelial compartments, including stromal (SC), osteoblastic (OB), macrophage (Macro), perivascular (Peri), adipogenic (Adipo), and hematopoietic stem and progenitors (HSPC) and endothelial (ECs) compartments (Fig

Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells

With modern lifestyles changing rapidly, our immune systems may be confused by processed foods, pollutants, and stress

[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

One-carbon metabolism-genome interactions in folate-associated pathologies

Histone deacetylases, and the sirtuin family, histone acetylases, and DNA methyltransferases are the main epigenetic factors modulated by aging, which, together with redox-sensitive transcription factors, trigger the metabolic shift toward the use of energy from aerobic glycolysis instead of mitochondria (422)