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the subunits of topoisomerases rely, in part on inter chain disulfides for their dual actions of catalysis and religation

Hence, several non-oral strategies have now been actively investigated and developed

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By applying these methods in combination with specific tracers, typical amyloid depositions and neurofibrillary tangles (NFTs) can reliably be visualized in mild cognitive impairment (MCI) subjects, a prodromal stage of AD, and early-stage AD patients [3336]

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Similar findings were also reported in PMA-stimulated mouse and human neutrophils where inhibition of G6PD significantly impaired their ability to undergo oxidative burst (64)