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[17] Meta-analyses of L-carnitine-the formulations primary shuttle for long-chain fatty acids-show modest but statistically significant reductions in body weight and body-mass index in adults with overweight or obesity

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Preclinical and animal studies validate the clinical findings on AOD 9604 by demonstrating its clear impact on fat metabolism and 3-adrenergic receptor activity

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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown