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FIGURE 4 The brain-derived neurotrophic factor (BDNF) pathway is considered an important molecular link between GC signaling and LTP regulation

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Indeed, there is evidence that co-targeting IGF-1R and Src family kinases by combining anti-IGF-1R mAbs/IGF-1R TKIs with dasatinib resulted in more effective growth inhibition than single-agent treatments in rhabdomyosarcoma cell lines [150]

doi:10.1039/C7SC04607C 20

The mitochondrial metabolism inhibitor CPI-613 in combination with high-dose Ara-C and mitoxantrone is highly active in poor-risk relapsed or refractory acute myeloid leukemia