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doi: 10.1134/S1021443721050150 158 RostonR

Reinhardt RR, Bondy CA: Insulin-like growth factors cross the bloodbrain barrier

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[DOI] [PubMed] [Google Scholar] 193.Sikiric P., Seiwerth S., Rucman R., Kolenc D., Vuletic L.B., Drmic D., Grgic T., Strbe S., Zukanovic G., Crvenkovic D., et al

Its deficiency can lead to scurvy due to impaired collagen formation affecting bones, blood vessels and skin

However, these symptoms usually take years to manifest, and fortunately, once diagnosed the deficiency is easily treated with vitamin B12 supplements