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and patients with pernicious anemia who have optic neuropathy COBALAMIN (Vitamin B12) Deficiency Causes Vegetarians (dietary deficiency) Older adults: atrophic gastritis affects 10% 30% and leads to decrease in hydrochloric acid secretion in the stomach and decreased absorption of Vitamin B12 The liver can store up to six years worth of Vitamin B12 so deficiencies are rare Effects of deficiency Megaloblastic anaemia (pernicious anaemia) Progressive demyelination of nerve cells Elevation in levels of circulating homocysteine that leads to production of defective collagen and elastin with a negative impact on arteries, bone and skin Deep vein thrombosis is associated with homocysteinemia that causes the activation of the intrinsic coagulation cascade Symptoms include fatigue, weakness, constipation, loss of appetite and weight loss Numbness, tingling of the feet imbalance, depression, confusion, dementia, poor memory and glossitis

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Collagen and elastin remodeling continues for 4 to 6 months after a consistent bi-weekly protocol begins

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Sublingual (SL) route of vitamin B12 administration: Injections for Vitamin B12 Deficiency hydroxocobalamin and cyanocobalamin

A combinao deve ser avaliada para garantir melhor desempenho e segurana na rotina de cuidados.AdvertnciasEm caso de reaes adversas, suspender o uso e procurar orientaoRecomenda-se o uso conforme orientao de um profissional habilitadoContraindicaesPessoas com hipersensibilidade a qualquer componente da frmulaGestantes, lactantes e menores de 18 anos somente com orientao profissionalO uso em excesso pode ser prejudicial, devendo sempre respeitar a recomendao de usoOrientaesSiga corretamente o modo de usoProduto indicado preferencialmente para adultosImagens meramente ilustrativasArmazenamentoManter fora do alcance de crianasArmazenar em local fresco, seco e protegido da luzConservar em temperatura ambiente entre 15 C e 30 CNo utilizar o produto com o prazo de validade vencido SE PERSISTIREM OS SINTOMAS, O MDICO DEVER SER CONSULTADO