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BHB, one of the KBs, can also enhance oxidative brain metabolism, resulting in the production of gamma-aminobutyric acid (GABA) (27), GABA B activation (24), the induction of synaptic recycling of glutamate loaded vesicles (24, 28), activation of K ATP (18), activation of two-pore domain potassium channels (K2P) (20), and the decrease of acid-sensing channels (ASICs) (29), thereby dampening neuronal excitability (20)
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