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Description
IDO1, Indoleamine 2,3-dioxygenase 1
Liver diseases, particularly cirrhosis, suppress CYP activity due to parenchymal changes, reduced blood flow, and loss of functional hepatocytes, leading to impaired drug metabolism and detoxification ( Type 2 Diabetes (T2D) alters CYP activities in an isoform-dependent manner: CYP2C19, CYP2B6, and CYP3A4 activities are reduced by 1.52-fold, whereas other isoforms may be unaffected or slightly increased ( The brain also expresses resident CYP enzymes at the tissue level, the blood-brain barrier, and the cerebrospinal fluid barrier, with roles in xenobiotic metabolism, homeostasis, and disease modulation (Wang and Zuo, 2018)
10.1016/j.phrs.2017.10.013 73 ZhouH.WangS.ZhuP.HuS.ChenY.RenJ
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doi: 10.1016/j.plefa.2007.10.021
