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DP2 documentation should include: technical reports describing results and conclusions of existing work, particularly regarding the commercial opportunity or DoD insertion opportunity, and risks/mitigations, assessments

This type of relationship is called a genotype environment (G E) interaction

Epidiolex was previously approved for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome

10 , e0126940 (2015)

Gut commensal microbiota metabolites serve as a significant source of AhR agonists (87)

The microbiota can initiate an anti-inflammatory or pro-inflammatory program based on the metabolites produced