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These include dopamine leakage from synaptic vesicles, an increased rate of dopamine conversion to DOPAL due to upregulated monoamine oxidase, and a decrease in DOPAL degradation caused by aldehyde dehydrogenases

doi: 10.4049/jimmunol.169.2.1126

Int Rev Neurobiol 91: 235288, 2010

Patients with depression often exhibit an increase in T helper 17 (Th17) cells and a decrease in Tregs, with inflammatory cytokines like IL-6 promoting Th17 differentiation while inhibiting Treg development (Sharifi et al., 2023)

However, even with multiple Helicobacter pylori eradication regimens, increased antibiotic resistance remains a major cause of eradication failure, owing to increased antimicrobial drug resistance and epidemiologic changes (82)