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when this process is compromised, Fe + activates lipid peroxidases, producing reactive oxygen species (50), which oxidize membrane polyunsaturated fatty acids (PUFAs) to PUFA-OOHs, resulting in irreversible membrane damage and cellular apoptosis ( Figure 4 )

Acknowledgements Work in T.P.s laboratory was supported by NIH grants (R37CA222504, R01CA227649, R01CA283049, R01CA262562 and R01CA297605) and an American Cancer Society Research Scholar Grant (RSG-17-200-01TBE)

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