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Vitamin C does not seem to cause significant adverse or toxic effects, and as such there is no upper limit, but very high doses, over 1000mg have been linked to gastrointestinal discomfort, including nausea, cramps and diarrhoea

& Kremling, A

When antioxidant capacity, particularly glutathione peroxidase (GPx) activity, is insufficient, oxidative stress can accumulate and damage thyroid proteins, including thyroid peroxidase (TPO)
(Yang et al

Treatments such as iron infusion therapy are prescribed to address diagnosed deficiencies or medical conditions
Then, a CD71 aptamer (Apt) was covalently linked to a Glut1 siRNA (siG) via a disulfide bond to yield a DNA-siRNA hybrid sequence (AsiG) that imparted capabilities of PDAC cells-specific targeting (due to the overexpression of CD71 receptor on the PDAC cells) and GSH-responsive drug release to siG (Supplementary Table 3 and Supplementary Fig