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MAO-A is more dominant in the heart, platelets, gut, and certain neurons, while MAO-B is prevalent in astrocytes and specific brain regions, as well as in the heart, intestines, kidneys, and blood vessels.[ref][ref][ref] Variants in the MAOA gene sometimes called the warrior gene can affect neurotransmitter levels and have been linked to changes in mood, aggressiveness, and response to antidepressants

In clinical trials such as SURPASS-2, tirzepatide demonstrated greater efficacy in type 2 diabetes compared to semaglutide 1 mg, with patients achieving substantial reductions in hemoglobin A1c levels and body weight

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[DOI] [PubMed] [Google Scholar] Schrenk D., Dekant W., Wnsch P.H., Henschler D