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Nose to brain delivery of astaxanthinloaded nanostructured lipid carriers in rat model of Alzheimer's disease: preparation, in vitro and in vivo evaluation

Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells

10.1177/2042018819863226 52 GuanY.-M.DiaoZ.-L.HuangH.-D.ZhengJ.-F.ZhangQ.-D.WangL.-Y.et al (2021)

Separate long-term post-transplant follow-up of pediatric liver recipients shows that with good graft function, the anthropometric characteristics of children can be fully restored and do not differ from those of healthy children of the same age

Beyond pharmacologic replacement, several non-pharmacological interventions can modulate the GH/IGF-1 axis: a) regular physical activity and cardiac rehabilitation increase physiological GH pulsatility and IGF-1 levels, improving skeletal muscle function and exercise capacity, b) nutritional optimization and correction of cachexia support IGF-1 synthesis and may partially reverse GH resistance, c) treatment of IR and obesity (e.g., with SGLT2 inhibitors and GLP-1 RAs) may indirectly normalize GH/IGF-1 dynamics by improving metabolic status, sleep quality and systemic inflammation, thus creating a more favorable hormonal milieu for the failing heart

Cancer risk in children and young adults conceived by in vitro fertilization
