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Additionally, intracellular invasion of tumor cells with attenuated Salmonella leads to NLRC4 and NLRP3 inflammasome formation and caspase-1 activation, culminating in mature IL-1 and IL-18 secretion, which triggers tumor cell pyroptosis (further details are provided in section 4.1), an explosive and highly immunogenic form of cell death ( 4.1.2 Bridging to adaptive immunity and immunological memory The activation of innate immunity favors the development of adaptive immunity

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Therapeutic application of monoclonal antibodies in pancreatic cancer: advances, challenges and future opportunities

doi: 10.1002/bdr2.1741
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2014 Aug;121(8):799-817
