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[DOI] [PMC free article] [PubMed] [Google Scholar] 252.Hyttinen J., Blasiak J., Tavi P., Kaarniranta K

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Materials and methods Chemicals preparation Tween 20 and CAR were purchased from Merck Millipore (Darmstadt, Germany) and Sigma-Aldrich (282197, Germany)

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Methods for identification of the DMF targetome As mentioned, the therapeutic efficacy of DMF was mainly attributed to KEAP1 succination, which resulted in stabilization of NRF2 leading to activation of the antioxidant response element (ARE)

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Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

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While NOX2 plays a role in the killing of bacteria and fungi, it enhances the pathology caused by viruses of low and high pathogenicity, including influenza A viruses [100]

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These transporters have a finite capacity that becomes saturated at higher doses, consequently causing absorption efficiency to decline sharply

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