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Ans Any heart related health issues occur due to accumulation of arterial plaque with the artery walls

Heart failure symptoms (rare, mostly in those with underlying heart disease): Shortness of breath Swelling in ankles or feet Rapid weight gain

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Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve

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Serum B12 concentration, dietary B12 intake and supplements use were not significantly associated with mortality risk (each p0.388)