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It has been found that mutations in the amyloid protein precursor ( APP ), presenilin-1 ( PSEN1 ), and presenilin-2 ( PSEN2 ) genes are associated with autosomal dominant early-onset familial AD, while apolipoprotein E4 ( APOE4 ) represents the most significant genetic risk factor for late-onset sporadic AD, contributing to the deposition of A peptides and hyperphosphorylated tau proteins (Rao et al., 2025)

The impact of ACE2 polymorphisms on COVID-19 disease: susceptibility, severity, and therapy

AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism

While alternative administration routes, such as intravenous, intramuscular, nasal, percutaneous, and transdermal delivery, have shown promise in certain conditions, these methods can be invasive and uncomfortable for patients