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J Alzheimers Dis 60: 439450, 2017

Desai N, Sharma R, Makker K, Sabanegh E, Agarwal A

CF airways feature intense inflammation and high H 2 O 2 production from phagocytes (Galli et al., 2012)

In line, the antihyperglycemic drug metformin which activates AMP-activated protein kinase (AMPK) but blocks mTOR signaling (and thereby glycolysis) and which also inhibits the OXPHOS cycle by interfering with the electron transport chain interfered with both -glucan- and oxLDL-induced trained immunity of monocytes (Keating et al., 2020)
GLY was administered to these ALF models to evaluate the degree of ferroptosis, and the corresponding pathway changes, in hepatocytes

Genes and Dis