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The strategy was presented in Fig

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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

fermentum A51 in MRS liquid medium was determined, and the results are shown in Figure 5A

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