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It also induces the reverse transport of these transporters ( 2.1.2 Vesicular monoamine transporter 2 inhibition METH inhibits vesicular monoamine transporter 2 and disrupts monoamine storage in synaptic vesicles ( 2.1.3 Calcium dysregulation and excitatory neurotransmission METH enhances glutamate release, leading to NMDAR overactivation and increased calcium influx into neurons ( 2.1.4 BBB disruption METH compromises BBB integrity, allowing peripheral immune cells to infiltrate the CNS ( 2.2 Neurotoxic mechanisms METH induces neurotoxicity via a combination of oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation

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