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In native form, IGF-1 is tightly regulated by these proteins, limiting free circulating activity

Anti PD-L1 therapy should be the first cancer treatment for any solid tumor with deficient mismatch repair genes or MSI-high

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Cancer Res 2001 61 : 49614965 Palmer K, Hitt M, Emtage PC, Gyorffy S, Gauldie J

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doi: 10.1038/s41467-023-43550-2, 20
