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Mg2+ deficiency also causes depolarization of the mitochondrial membrane potential (m) [131] by promoting the opening of the mitochondrial ATP-sensitive potassium (K) channel [132], the anion channel of the inner membrane (IMAC) [133] and the mitochondrial permeability transition pore (PTP) [134]

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This overall change in gene expression suggests that the intracellular network regulating cell cycle progression and DNA replication under RRM2 overexpression conditions undergoes systematic remodeling, which may lead to abnormal acceleration of the cell cycle and sustained activation of proliferative signals

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doi: 10.32523/2616-7034-2024-149-4-50-62 139 SamynathanR.VenkidasamyB.ShanmugamA.RamalingamS.ThiruvengadamM

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