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In the endogenous apoptotic pathway, various cellular stress, such as nuclear DNA damage, cytokine deprivation, endoplasmic reticulum stress (ERs), lysosomal permeabilization, and oxidative stress generate intracellular death signals to promote mitochondrial dysfunction and subsequently mitochondrial outer membrane pore formation (MOMP)

doi: 10.34067/KID.0001822021 139 Russell-HallinanAKarunaNLezoualchFMatulloGBakerHBernardMet al

832 miR-20a-5p is significantly upregulated in kidney transplantation patients and mice with acute kidney injury

In silico predictive modeling Based on the binding pose observed for THC in the X-ray structure, we used the program DOCK 28 to computationally predict binding geometries of the primary THC metabolite 11-OH-THC, secondary THC metabolite THC-COOH, the THC isomer CBD, and the cannabinoid analog AJA