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10.1111/cns.13548 CNS Neurosci

507 However, hyperactive IRE1 signaling is also associated with -cell deficits, and ATF4 and CHOP deletion may have protective effects against -cell dysfunction or T2D, suggesting that the UPR may also mediate apoptotic signaling in stressed -cells

Then, these AP sites are cleaved by an AP endonuclease

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