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Prospective BASECAMP-1 experience in patients with gastrointestinal (GI) cancer: Identifying patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for a future therapeutic trial exploiting LOH as a tumor vulnerability

It is generally accepted that NRF2 is sequestered by KEAP1 in the cytoplasm under normal conditions and is released from KEAP1 before translocating into the nucleus under oxidative stress (Figure 1)

TimeTree: A resource for timelines, timetrees, and divergence times

This change makes the molecule too hydrophilic to cross BBB, therefore high dose is needed for CNS application [16]

[What is the active oxygen ?] Active oxygen in the body is unstable state

J.MusnerN.OttoG.JanzM.et al (2017)