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Most of these studies have focused on uptake of DCVC across the basolateral (peritubular) membrane of the renal proximal cells

329 Research has found that lysosomal acidity is also within the realm of calcium regulation, where excessive Ca 2+ released from the ER-resident RyR receptor can impair the function of lysosomal V-ATPase, causing lysosomal acidification defects, reducing lysosomal protease activity, and leading to the accumulation of p-tau

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Many inducers (e.g., erastin, RSL3, RSL5, buthioninesulfoximine, acetaminophen, fin, lanperisone, sulfasalazine, sorafenib, and artesunate) and inhibitors (e.g., ferrostatin, liproxstatin-1, and zileuton) of ferroptosis have been identified, but the specific mechanisms and pathways are diverse (Xie et al., 2016)