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Furthermore, in vivo experiments showed that CNS exhibited therapeutic effects comparable to those of fluoxetine, effectively ameliorating symptoms of anxiety, despair, and anhedonia while also inhibiting microglial activation in the hippocampus of mice subjected to CUMS

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There is increasing evidence that the tumour microenvironment (TME) that comprises cancer cells, tumour stroma, blood vessels and immune infiltrate, promotes cancer progression and alters tumour sensitivity to therapy

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The KaplanMeier curve shown in Fig