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This is similar to the environmental changes that accompany ferroptosis

When assessing drug efficacy for the treatment of glioblastoma multiforme (GBM), currently, the most reliable models are generated through direct injection of patient-derived cells or more frequently the isolation of glioblastoma cells endowed with stem-like features and orthotopically injecting these cells into the cerebrum of immunodeficient mice

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Cancers 15 , 87 (2022)

In recent years, the question of whether there is a role for de-escalation of systemic neoadjuvant and adjuvant therapies has arisen