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P450 enzymes are also involved in the first step of the methylation pathway, where they convert methionine to S-adenosylmethionine (SAMe)

Specifically, GA increased beta-oxidation of fatty acids and elevated levels of ketone body metabolites which are produced during fatty acid catabolism

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Regenerative medicine for IVD degeneration, by injection of IVD cells, chondrocytes or stem cells, has been extensively studied in the past decade in various animal models of induced IVD degeneration, and has progressed to clinical trials in the treatment of various spinal conditions

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