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Compared to the neutral environment (pH = 7), a higher Cu 2+ concentration was observed at pH = 5, indicating that the CSp-OxD@Cu 2+ /G hydrogel releases more active components under weakly acidic conditions, which is consistent with the expected results (Figure S10)

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Attempts to generate HPi2-directed CAR-Tregs using anti-HPi2 scFv failed because the antibody was broadly expressed on CD4 T cells, rendering the approach non-viable (77)