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This review highlights a randomized controlled crossover study that explored the therapeutic benefits of cocoa on reducing fatigue and enhancing residual functions in ME/CFS patients, as measured by the London Handicap Scale

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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)

Perdomo CM, Cohen RV, Sumithran P, Clment K, Frhbeck G