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On the one hand, when the WNT pathway is activated, ICAT blocks the interaction of -catenin-APC and inhibits the degradation of -catenin by competing with APC for the binding site of -catenin

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Remarkably, 5-cholesten-3-one, derived by oxidation of the 3-hydroxyl group of cholesterol, is not a substrate in spite of a structure of the A and B rings identical to that in 5-AD and 5-PD, in which the double bond isomerization occurs (Figure 2)

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