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Note, a triple regimen (NO-system inhibition, over-stimulation, and immobilization simultaneously tested under the same experimental conditions) may reveal the particular complexity of NO-system functioning when the NO-system as a whole was investigated

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TABLE 9 Plasma pharmacokinetic parameters examined based on total radioactivity following a single intramuscular administration of 100 g/300 Ci/kg of [3H]BPC157 in rats (mean SD, n = 6)

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These results combined with the normal initial respiratory burst in the first few minutes following PMA stimulation in Gsr / neutrophils (33, 34) strongly suggest that NADPH oxidase assembly, at least in the early phase, is not affected by Gsr deficiency