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This contrasts sharply with orthobiologic therapies like PRP and mesenchymal stem cell therapies, both of which have been evaluated in multiple randomized controlled trials and large observational studies

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If the ordered dose is less than or more than the SDR, hold the medication and clarify promptly

Animal studies reveal dose-dependent teratogenicity, and limited human data show potential for fetal growth restriction and ambiguous genitalia

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doi: 10.1097/00005792-199603000-00003