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Nature Communications 6, 5928

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Study the function of proteins by differentiating different functional domains

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Considering that oxidative stress generally interacts with inflammation to form a complex pathological microenvironment, multifunctional nanomedicine may achieve a synergistic effect and obtain optimal therapeutic outcomes [203, 204]

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Lakhdar H, Zouhair K, Khadir K, Essari A, Richard A, Seite S, et al

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However, it is now well understood that antioxidant action is much more complex than free radical scavenging, and is based on the modulation of complex signaling pathways to activate endogenous, primarily enzymatic antioxidant defense mechanisms [166]

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While GSH has long been recognized as a key brain antioxidant, its role in neurodegenerative diseases is now being unraveled with mechanistic clarity: future research will likely focus on activating astrocytic Nrf2 signaling to enhance glutamate cysteine ligase (GCL)-mediated GSH synthesis, exploring the role of MCT1/2 transporters in neuronal GSH precursor supply, and dissecting how oxidative stress modulates microglial activation via pathways like NF-B-dependent proinflammatory cytokine secretion (Sun et al., 2022)

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