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(2017) 12:e0186802

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Roitman, S., Greenfield, D

Numerous studies have shown that the amyloid beta peptide exerts neurotoxic effects possibly via mitochondrial dysfunction [20,79,80,81]

In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [88-90]

31 Mean pain intensity score, evaluated using the modified short-form MPQ, was significantly lowered during the study, whereas electrophysiological parameters did not show significant changes