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Folate is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are critical for mood regulation, cognitive function, and overall mental well-being (, )

The EFSA notes, The inherent uncertainty of this [factorial] approach is reflected in the wide range of cobalamin intake calculated to compensate for estimated daily losses, depending on the assumptions taken (EFSA, 2015). Appendix D