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Physiol Rev 2009;89:14791

BM adipocytes have higher FABP4 expression and promote lipid transport to support the activities of AML cells, and FABP4 can activate the downstream peroxisome proliferator-activated receptor (PPAR) to further induce gene transcription of CD36, FABP4, and BCL2 in AML cells (140)

The majority of mutations identified were missense

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Despite no significant difference in the total bacterial load, specific bacterial taxa were differentially abundant, with the presence of Streptococcus in the ESCC TME correlating with an activated tumor immune microenvironment and improved therapeutic efficacy of neoadjuvant chemotherapy combined with immunotherapy

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