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84:424-427 [PubMed: 10022395] 261

An advantage of on-column cleavage is the high level of purity obtained, but this comes at the expense of generally low yield due to less efficient protease cleavage and decreased control of the digestion conditions

doi:10.1093/jn/130.5.1399S Shankar AH, Prasad AS

D., Cui, P

Moreover, a review of curcumin-based nanoformulations summarized that most designs employ biocompatible polymers and coatings to mitigate toxicity

The mechanism determines whether a hit advances or gets dropped, whether toxicity is on-target or off, and what downstream immune and inflammatory responses to expect
