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Four trials used EPA (0.70-0.84 g/day) plus DHA (0.46-0.70 g/day) (178-181), one trial used DHA (0.24 g/day) plus AA (0.24 g/day) (177), and one trial only used only DHA (0.20 g/day) (182)

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51,52 Although medications such as baclofen, tizanidine, and clonazepam used for treating spasticity and stiff-person syndrome can be helpful in managing neurogenic muscle cramps (likely due to the central contributions to cramp propagation), there is limited evidence for use in muscle cramps not associated with spasticity

Choline, inositol, and methionine are studied for their roles in hepatic phosphatidylcholine production (required for VLDL export of fat from the liver), methylation cycle function, and one-carbon metabolism pathways central to NAFLD and metabolic syndrome research