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Methods Data search strategy To explore the molecular and epigenetic effects of kratom, we conducted a systematic literature review guided by the PRISMA 2020 framework

Plus, some products have been known to contain contaminants, specifically the mycotoxin citrinin

Beyond that window, potency loss accelerates: studies on similar melanocortin peptides show 1525% degradation by day 45 and upward of 40% loss by day 60, even under continuous refrigeration

10.1016/j.pmedr.2018.10.008 72 HazratiE.EftekharS

Furthermore, it has been reported to reduce cellular senescence and suppress the SASP

This family of proteins can activate or inhibit a variety of target genes, such as p27kip1 and cyclin D (CCND) CYR61, which regulate the cell cycle, the bim and fasL genes that mediate apoptosis [40], TNF and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) [41], and the RAD51 gene involved in DNA damage repair