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ChemBioChem 2015, 16, 14839
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Covalent thiol adduct formation enhances the quantum yield and can thus be detected as an increase in the fluorescence emission as was illustrated for recombinant cSrc S345C mutant (Cys345 mutation on an isostructural position to Cys797 in EGFR) with irreversible covalent quinazoline PD168393 but not with a noncovalent analogue [142]
Research has focused on its role in fat metabolism, adipogenesis inhibition, and metabolic regulation
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