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However, increased ROS production in PD is closely linked to mitochondrial dysfunction (Weng et al., 2018) The discovery that mutations in the genes encoding proteins like -syn, parkin, DJ-1, or PINK are associated with familial types of PD raises the question of how oxidative stress and dopamine (DA) cell damage are related to mitochondrial dysfunction (Gonchar et al., 2019

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18 , e1010472 (2022)

The present study had a number of limitations

However, the interaction surface of p65 does not appear to include the DNA-binding domain, suggesting that inhibition may occur through allosteric modulation