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However, upon interaction with lipid membranes, it adopts an -helical conformational change, and under conditions that trigger aggregation, Syn undertakes the characteristic crossed -conformation and self-aggregates into soluble oligomers, which gradually form insoluble amyloid-like fibrils

In addition, combined therapy of TCM and selenium supplementation exerted a greater beneficial effect on the titer of thyroid autoantibodies and clinical symptoms than selenium supplementation alone [62]

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