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To elucidate the topographical characteristics of SBS-PolkKO mutations across the mouse genome 46,47 , we characterized the SBS-PolkKO signature using SigProfilerTopography 47

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Studies revealed that many COVID-19 patients had severely depleted glutathione stores, potentially contributing to the oxidative damage seen in serious cases

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In all three of these aforementioned clinical treatment studies performed by the authors, biomarkers of redox and methylation metabolism were measured