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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

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Therefore, monitoring of the platelet count and serum potassium concentrations are recommended during therapy

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When B12 levels are low, red blood cells can become large and inefficient, contributing to fatigue and weakness

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Gong B et al