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While ex vivo IR studies have demonstrated cardioprotection with p66shc deletion 62 , in vivo IR studies have yielded the opposite effect 63,64
WB showed increased p-mTOR, Raptor, p-4E-BP1, p-S6, Bcl-2 and p62, while decreased Bax, Apaf-1, cleaved caspase-3, Beclin, and LC3-I/II
Endocrinology 145 , 40374047 (2004)
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